反应详情

According to this process, ethyl (±)-4,4,4-trifluoro-3-hydroxybutanoate is converted to the sodium salt of the corresponding butanoic acid which is hydrolysed to give (±)-4,4,4-trifluoro-3-hydroxbutanoic acid, this acid is reacted with (S)-α-methylbenzylamine, the (S)-α-methylbenzylamine salt of 4,4,4-trifluoro-3(R)-hydroxybutanoic acid is separated from the mixture of diastereoisomers formed by crystallization from ethanol and this salt is then hydrolysed in acid medium to produce 4,4,4-trifluoro-3(R)-hydroxybutanoic acid. 4,4,4-Trifluoro-1,3(R)-butanediol is then obtained by reduction of 4,4,4-trifluoro-3(R)-hydroxybutanoic acid.

1. customto give (±)-4,4,4-trifluoro-3-hydroxbutanoic acid
2. customthe (S)-α-methylbenzylamine salt of 4,4,4-trifluoro-3(R)-hydroxybutanoic acid is separated from the mixture of diastereoisomers
3. customformed by crystallization from ethanol