Benzene → 1,1,1-trifluoro-2-phenylpropan-2-ol

HRID 861833Notes

Reaction equation

HRID 861833 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([CH3:5])=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].[CH:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([OH:4])[CH3:5]

Participants

4

Reactant 3

HCID 241BenzeneHCID 9871Methyl trifluoromethyl ketoneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 1235801,1,1-trifluoro-2-phenylpropan-2-ol

Procedure

1,1,1-Trifluoro-2-phenylpropan-2-ol was prepared from benzene and 1,1,1-trifluoroacetone by an AlCl3 -catalyzed Friedel-Crafts reaction.

Sources & evidence

ORD record
ord-3c25088825e149fca836efe8b0706d00
Source dataset
uspto-grants-1998_02
Patent number
US05716756

Reaction notes

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