Potassium Cyanide → 1-Cyano-1-phenyl-2,2,2-trifluoroethanol

HRID 861835Notes

Reaction equation

[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[C-:13]#[N:14].[K+]>>[C:13]([C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([OH:4])[C:2]([F:11])([F:12])[F:1])#[N:14]

Participants

Reactant 2

HCID 9032Potassium Cyanide

HCID 99052,2,2-Trifluoroacetophenone

Product 1

HCID 46073381-Cyano-1-phenyl-2,2,2-trifluoroethanol

Procedure

1-Cyano-1-phenyl-2,2,2-trifluoroethanol was prepared from α,α,α-trifluoroacetophenone by a cyanohydrin reaction with potassium cyanide.

Sources & evidence

ORD record: ord-05d3fa320c464ac0bbce700f6771436b
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05716756

Reaction notes

Loading…