Triethyl phosphite → HCID 54010371, compound

HRID 861883Notes

Reaction equation

Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([N+:13]([O-])=O)=[CH:5][CH:4]=1.[CH2:16]([O:18][P:19]([O:23]CC)[O:20][CH2:21][CH3:22])[CH3:17]>>[NH2:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([CH2:2][P:19](=[O:23])([O:20][CH2:21][CH3:22])[O:18][CH2:16][CH3:17])=[CH:4][CH:5]=1

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 127491631-(Bromomethyl)-4-nitronaphthalene

Product 1

HCID 54010371HCID 54010371, compound

Procedure

1-Bromomethyl-4-nitronaphthalene and triethylphosphite ((C2H5 O)3P) were treated in the same manner as in Reference Example 43 to yield diethyl (4-amino-1-naphthyl)methylphosphonate, which was then recrystallized from ethyl acetate-hexane to yield yellow prisms having a melting point of 73°-74° C.

Sources & evidence

ORD record: ord-c421f90753d44f4bae1116845c78c40c
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05716944

Reaction notes

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