Trimethyl phosphite → 2-Dimethoxyphosphorylmethyl-5-nitrothiophene

HRID 861884Notes

Reaction equation

Br[CH2:2][C:3]1[S:4][C:5]([N+:8]([O-:10])=[O:9])=[CH:6][CH:7]=1.[CH3:11][O:12][P:13]([O:16]C)[O:14][CH3:15]>>[CH3:11][O:12][P:13]([CH2:2][C:3]1[S:4][C:5]([N+:8]([O-:10])=[O:9])=[CH:6][CH:7]=1)([O:14][CH3:15])=[O:16]

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 536851562-(Bromomethyl)-5-nitrothiophene

Product 1

HCID 197005052-Dimethoxyphosphorylmethyl-5-nitrothiophene

Procedure

2-Bromomethyl-5-nitrothiophene and trimethylphosphite ((CH3O)3 P) were treated in the same manner as in Reference Example 43 to yield 2-dimethoxyphosphorylmethyl-5-nitrothiophene as an oil.

Sources & evidence

ORD record: ord-3c413eb989ee424b802a5f153e1958b6
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05716944

Reaction notes

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