反应详情

温度

85 °C

To a solution of 2-(3-nitrobenzoyl)-3-methoxycarbonylpyridine (0.20 g, 0.75 mmoles) dissolved in ethanol (50 ml), was added benzylhydrazine hydrochloride (0.36 g, 1.86 mmoles). The mixture was heated to 85° C. for 144 hours. The mixture was purified by chromatography yielding 0.11 g of 6-benzyl-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one (41%), mp 132° C.

1. customThe mixture was purified by chromatography