HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861953Generated: November 2, 2026
Hydrazine, (phenylmethyl)-, hydrochloride (1:1) → 6-Benzyl-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one
https://huagongshe.com/reaction/861953
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine, (phenylmethyl)-, hydrochloride (1:1) | HCID 14084 | — |
| Reactant | 2-(3-Nitrobenzoyl)-3-methoxycarbonylpyridine | HCID 19700716 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Benzyl-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one | HCID 19700884 | 41% |
Reaction Steps
To a solution of 2-(3-nitrobenzoyl)-3-methoxycarbonylpyridine (0.20 g, 0.75 mmoles) dissolved in ethanol (50 ml), was added benzylhydrazine hydrochloride (0.36 g, 1.86 mmoles). The mixture was heated to 85° C. for 144 hours. The mixture was purified by chromatography yielding 0.11 g of 6-benzyl-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one (41%), mp 132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05716954 |
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| Source dataset | uspto-grants-1998_02 |
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| ORD ID | ord-bd4105b67b4e4ff6b55839b5ca503038 |
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| Source note | uspto-grants-1998_02 |
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