Hydrazine hydrate (1:1) → HCID 19700680, compound

HRID 861958Notes

Reaction equation

HRID 861958 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[C:5]([C:7]1[C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=[CH:9][N:8]=1)=O.O.[NH2:21][NH2:22]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:7]3[N:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:13](=[O:14])[NH:22][N:21]=2)[CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19700909HCID 19700909, compound

Product 1

HCID 19700680HCID 19700680, compoundYield 50.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(3-chlorobenzoyl)-3-methoxycarbonylpyridine (0.55 g, 2.0 mmoles), hydrazine hydrate (0.15 ml, 3.0 mmoles) in ethanol (50 ml) was stirred at 100° C. for 18 hours under an inert atmosphere. The solution was cooled and solid in the solution was collected, washed with ethyl ether and dried to give 0.26 g of 8-(3-chlorophenyl)pyrido-[2,3-d]pyridazin-5-one (50.5%), mp 268°-269° C.

Workup

  1. temperatureThe solution was cooled
  2. customsolid in the solution was collected
  3. washwashed with ethyl ether
  4. customdried

Sources & evidence

ORD record
ord-a5e4096854c746568c9fc29fbd27e801
Source dataset
uspto-grants-1998_02
Patent number
US05716954

Reaction notes

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