RS 14203 → 6-(4-Pyridylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one hydrochloride

HRID 861966Notes

Reaction equation

HRID 861966 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[C:13](=[O:14])[C:12]3[CH:15]=[CH:16][CH:17]=[N:18][C:11]=3[C:10]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=3)=[N:9]2)=[CH:3][CH:2]=1.[ClH:28].CO>CO>[ClH:28].[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[C:13](=[O:14])[C:12]3[CH:15]=[CH:16][CH:17]=[N:18][C:11]=3[C:10]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=3)=[N:9]2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 9808563RS 14203HCID 21893726Hydrochloride methanol

Product 1

HCID 197008946-(4-Pyridylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 6-(4-pyridylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one in methanol is added 5% HCl/MeOH in a dropwise manner with stirring until a clear solution is obtained. The solvent is stripped off. The resulting solid is triturated with ethyl ether. The product is filtered off and dried under vacuum yielding 6-(4-pyridylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one hydrochloride.

Workup

  1. customis obtained
  2. customThe resulting solid is triturated with ethyl ether
  3. filtrationThe product is filtered off
  4. customdried under vacuum

Sources & evidence

ORD record
ord-cde025d4d2fa43d495d8c216eeeae18d
Source dataset
uspto-grants-1998_02
Patent number
US05716954

Reaction notes

Loading…