反应详情

The 7-hydroxy-7-(3-nitrophenyl)-6-(n-butyl)-6,7-dihydropyrrolo[3,4-b]pyridin-5-one was mixed with 500 mL of water and 250 mL of concentrated hydrochloric acid was added. The mixture was heated under reflux for 20 hours. After cooling the mixture was diluted with 500 mL of water and the solid was removed by filtration. After washing the solid with water (500 mL) and methanol (200 mL) the material was dried to give 39.85 of 7-hydroxy-7-(3-nitrophenyl)-7H-furo[3,4-b]pyridin-5-one.

1. additionwas added
2. temperatureThe mixture was heated
3. temperatureunder reflux for 20 hours
4. temperatureAfter cooling the mixture
5. customthe solid was removed by filtration
6. washAfter washing the solid with water (500 mL) and methanol (200 mL) the material
7. customwas dried