HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-Amino-2-pyridinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-[6-(Bromomethyl)pyridin-2-yl]-2,2-dimethylpropanamide | HCID 14326706 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 6-Amino-2-pyridinemethanol | HCID 11182606 | 71% |
Reaction Steps
The product of Example 2 (24.89 g, 96 mmol) and 10% (v/v) H2SO4 (100 mL) were combined in a 250 mL flask. The reaction was heated to reflux for 8 h and then cooled to room temperature. The reaction was made basic with aq K2CO3 and extracted with EtOAc. The extracts were dried (MgSO4), decolorized with activated charcoal, and filtered. Removal of all solvent in vacuo gave 8.49 g (71%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05716964 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-426534e4e3a345d9a21b2e71ae533e8f |
| Source note | uspto-grants-1998_02 |