反应详情

A solution of methyl N-CBZ-α-methyl-3-benzothiophenylalanine (0.6 g, 1.57 mmol), lithium hydroxide hydrate (0.14 g, 3.33 mmol) in water (20 mL), and dioxan (20 mL) was stirred at room temperature overnight. The reaction mixture was diluted with water, washed with ether, acidified with 1N hydrochloric acid, and extracted with ethyl acetate three times. The combined extracts were washed with water, dried over magnesium sulphate, filtered, and evaporated to dryness. Crystallization from ether/hexane gave colorless crystals 0.48 g (83%); mp 133°-135° C.;

1. washwashed with ether
2. extractionextracted with ethyl acetate three times
3. washThe combined extracts were washed with water
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customevaporated to dryness
7. customCrystallization from ether/hexane