反应详情

温度

50 °C

To a solution of 2-(5-bromo-4-chloro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine (7.73 g) in methanol (250 ml) was added hydrochloric acid (12.5 ml), which was stirred for 5 hours at 50° C. Methanol was distilled off under reduced pressure. To the residue was added ethyl acetate (5 ml), which was poured into water. Crystalline precipitate then formed was collected by filtration, washed with ethyl acetate 10 and dried to give 2-(5-bromo-4-chloro-2-hydroxybenzoyl)-3-hydroxypyridine (5.95 g) (Compound A-8).

1. distillationMethanol was distilled off under reduced pressure
2. additionTo the residue was added ethyl acetate (5 ml), which
3. additionwas poured into water
4. customCrystalline precipitate then formed
5. filtrationwas collected by filtration
6. washwashed with ethyl acetate 10
7. customdried