Hydrochloric Acid → HCID 136463798, compound

HRID 862095Notes

Reaction equation

HRID 862095 reaction equation
[C:1]([O:5]/[N:6]=[C:7](\[C:16]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][N:17]=1)/[C:8]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:9]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[ClH:23]>C(O)C>[ClH:23].[C:1]([O:5]/[N:6]=[C:7](\[C:16]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][N:17]=1)/[C:8]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:9]=1[OH:15])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135500039HCID 135500039, compound

Product 1

HCID 136463798HCID 136463798, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(Z)-2-(5-bromo-2-hydroxybenzoyl)-3-hydroxypyridine O-t-butyloxime (0.86 g) was dissolved in ethanol (20 ml), to which was added 2N-HCl (1.4 ml). The mixture was stirred for one hour at room temperature, then the solvent was distilled off under reduced pressure. The residue was crystallized with ethyl acetate to give (Z)-2-(5-bromo-2-hydroxybenzoyl)-3-hydroxypyridine O-t-butyloxime hydrochloride (0.31 g) (Compound 45).

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was crystallized with ethyl acetate

Sources & evidence

ORD record
ord-54792a33142147e294cc63da3bee1c4f
Source dataset
uspto-grants-1998_02
Patent number
US05716971

Reaction notes

Loading…