HRID862221

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N1CCCCC1C(=O)NC1CC(=O)OC1OCc1ccccc1)C(C)C

HCID66756123

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N1CCCCC1C(=O)NC(C=O)CC(=O)O)C(C)C

HCID86599022

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

To a solution of 100 mg of N-(N-Acetyl-tyrosinyl-valinyl-pipecolyl)-4-amino-5-benzyloxy-2-oxotetrahydrofuran in 10 ml of methanol was added 60 mg of Pd(OH)2 on carbon and the mixture placed under an atmosphere of hydrogen via a balloon. The mixture was filtered through Celite and concentrated providing a white solid. This crude solid was dissolved in 2 ml of methanol and triturated with diethyl ether affording 26 mg of the title compound.

WORKUP

后处理

filtrationThe mixture was filtered through Celite
concentrationconcentrated
customproviding a white solid
customtriturated with diethyl ether affording 26 mg of the title compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2dd66a67a9bf417ea6bf314aa92b9e51
来源数据集: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05716929
来源说明: uspto-grants-1998_02

反应 SMILES

[C:1]([NH:4][C@H:5]([C:14]([NH:16][C@H:17]([C:21]([N:23]1[CH2:45][CH2:44][CH2:43][CH2:42][CH:24]1[C:25]([NH:27][CH:28]1[CH:32]([O:33]CC2C=CC=CC=2)[O:31][C:30](=[O:41])[CH2:29]1)=[O:26])=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]>CO.[OH-].[OH-].[Pd+2]>[C:1]([NH:4][C@H:5]([C:14]([NH:16][C@H:17]([C:21]([N:23]1[CH2:45][CH2:44][CH2:43][CH2:42][CH:24]1[C:25]([NH:27][CH:28]([CH:32]=[O:33])[CH2:29][C:30]([OH:41])=[O:31])=[O:26])=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]