HRID862316

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CC[C@H]3[C@@H](CC=C4C=C(C#N)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O

HCID15380254

未命名化合物

HCID15754138

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)cc(C(C)(C)NC(=O)[C@H]2CC[C@H]3[C@@H]4CC=C5C=C(C#N)CC[C@]5(C)[C@H]4CC[C@]23C)c1

HCID57001892

未命名化合物

收率 98%

PROCEDURE

实验过程

Following a procedure similar to that described in Preparation 16a, but using 3-cyanoandrosta-3,5-diene-17β-carboxylic acid [prepared as described in Example 1(b)] and 1-(3,5-dimethoxyphenyl)-1-methylethylamine as starting materials, in relative proportions similar to those used in that Preparation, the title compound was obtained in a yield of 98%.

WORKUP

后处理

customin relative proportions similar to those used in that Preparation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a744a9b9026d438fa76e580f7dc1606b
来源数据集: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05717088
来源说明: uspto-grants-1998_02

反应 SMILES

[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](O)=[O:23])[CH:4]=1)#[N:2].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([C:35]([NH2:38])([CH3:37])[CH3:36])[CH:30]=[C:31]([O:33][CH3:34])[CH:32]=1>>[CH3:34][O:33][C:31]1[CH:30]=[C:29]([C:35]([NH:38][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:23])([CH3:36])[CH3:37])[CH:28]=[C:27]([O:26][CH3:25])[CH:32]=1