epsilon-CAPROLACTONE → Poliglecaprone

HRID 862366Notes

Reaction equation

HRID 862366 reaction equation
[CH2:1]1[O:8][C:6](=[O:7])[CH2:5][O:4][C:2]1=[O:3].[C:9]1(=[O:16])[O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH2:1]1[O:8][C:6](=[O:7])[CH2:5][O:4][C:2]1=[O:3].[C:9]1(=[O:16])[O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 10401epsilon-CAPROLACTONEHCID 65432Glycolide

Product 1

HCID 65431Poliglecaprone

Procedure

We have discovered a process for producing a suture from copolymers of glycolide and ε-caprolactone comprising the steps of (a) extruding a melted copolymer of a glycolide and ε-caprolactone resin through an orifice and rapidly quenching the melted copolymer resin to produce a filament; (b) drawing the filament in the range of from about 4× to about 7.5× to produce a singly drawn filament; (c) drawing the singly drawn filament in the range of form about 1× to about 3× in a first heated zone being maintained at a temperature in the range of from about 150° F. to about 450° F., to form a doubly drawn filament; (d) shrinking the doubly drawn filament in the range of from about 0.75 percent to about 0.98 percent, in a second heated zone being maintained at a temperature in the range of from about 100° F. to about 400° F., to form a relaxed filament then rack annealing the relaxed filament to form a glycolide/ε-caprolactone suture.

Workup

  1. customrapidly quenching the melted copolymer resin
  2. customto produce a filament
  3. customto produce a singly drawn filament
  4. temperaturebeing maintained at a temperature in the range of from about 150° F. to about 450° F.
  5. customto form a doubly drawn filament
  6. temperaturein a second heated zone being maintained at a temperature in the range of from about 100° F. to about 400° F.
  7. customto form a relaxed filament

Sources & evidence

ORD record
ord-35f01a18f9a4425da16e6d0393bbcd86
Source dataset
uspto-grants-1998_02
Patent number
US05718716

Reaction notes

Loading…