Hydrochloric Acid → HCID 53694428, compound

HRID 862387Notes

Reaction equation

HRID 862387 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]=[C:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])=[CH:4][CH:3]=1.Cl.[O-:20][C:21]#[N:22].[Na+]>>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[C:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])=[CH:17][CH:18]=1)[C:21]([NH2:22])=[O:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 517096Sodium CyanateHCID 53702970HCID 53702970, compound

Product 1

HCID 53694428HCID 53694428, compound

Procedure

A mixture of 3-(4-aminobenzylidene)-7-azaoxindole (2.373 g, 10 mmol) in ice water (20 ml) are added 5N HCl (2 ml, 10 mmol under stirring. Then the mixture was heated to 70°-80° C., sodium cyanate (0.715 g, 11 mmol) was added portionwise and the stirring was continued for further 4 h at this temperature.

Workup

  1. temperatureThen the mixture was heated to 70°-80° C.

Sources & evidence

ORD record
ord-d8473b28419f4a96befde8609b03b9de
Source dataset
uspto-grants-1998_02
Patent number
US05719135

Reaction notes

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