m-Tolyl isocyanate → HCID 70051448, compound

HRID 862409Notes

Reaction equation

HRID 862409 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])[C:6]2[CH:21]=[CH:22][CH:23]=[CH:24][C:5]=2[N:4]([CH3:25])[C:3]1=[O:26].[CH3:27][C:28]1[CH:29]=[C:30]([N:34]=[C:35]=[O:36])[CH:31]=[CH:32][CH:33]=1>>[CH3:25][N:4]1[C:5]2[CH:24]=[CH:23][CH:22]=[CH:21][C:6]=2[C:7]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])=[N:8][CH:2]([NH:1][C:35]([NH:34][C:30]2[CH:31]=[CH:32][CH:33]=[C:28]([CH3:27])[CH:29]=2)=[O:36])[C:3]1=[O:26]

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 15379623HCID 15379623, compound

Product 1

HCID 70051448HCID 70051448, compoundYield 94%

Procedure

By condensing 3-amino-1,3-dihydro-1-methyl-5-(2,4,6-trimethoxyphenyl)-1,4-benzodiazepin-2-one with 3-methylphenyl isocyanate, 1,3-dihydro-1-methyl-3-(3-methylphenylureido)-5-(2,4,6-trimethoxyphenyl)-1,4-benzodiazepin-2-one is obtained; m.p.=240° C., Yield=94%.

Sources & evidence

ORD record
ord-98fdd29b41d64a7cb0a9cbc7098ef389
Source dataset
uspto-grants-1998_02
Patent number
US05719143

Reaction notes

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