反应详情

A mixture of 2.0 g (11.41 mmol) of 8-amino-2-methylimidazo[1,2-a]pyridine-3-carboxaldehyde, 1.21 g (11.41 mmol) of anhydrous sodium carbonate, 0.17 g (1.14 mmol) of sodium iodide and 3.5 g (13.6 mmol) of 2-methoxyethyl 2-chloromethyl-3-methylphenylcarbamate in 30 ml of acetone is stirred at RT for 24 h and concentrated in a Rotavapor. The residue is treated with 100 ml of water and extracted with ethyl acetate, and the organic phase is dried with magnesium sulphate and concentrated in vacuo. The residue is recrystallized from toluene. 3.31 g (73%) of the title compound of m.p. 153°-155° C. are obtained.

1. concentrationconcentrated in a Rotavapor
2. additionThe residue is treated with 100 ml of water
3. extractionextracted with ethyl acetate
4. dry with materialthe organic phase is dried with magnesium sulphate
5. concentrationconcentrated in vacuo
6. customThe residue is recrystallized from toluene