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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 862657Generated: October 30, 2026

Lawesson's reagent → HCID 178470133, compound

https://huagongshe.com/reaction/862657

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLawesson's reagentHCID 87949—
Reactantethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylateHCID 22097611—
SolventTolueneHCID 1140—
ProductHCID 178470133HCID 17847013370.8%

Reaction Steps

A mixture of ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate (6.8 g), Lawesson's reagent (8.0 g) and toluene (250 ml) was stirred under reflux for 18 hours. After cooling, the precipitated crystals were collected by filtration to give ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-mercaptoquinoline-3-carboxylate (5.0 g, 70%) which was then recrystallized from acetone. mp. 265°-266° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05719157
Source datasetuspto-grants-1998_02
ORD IDord-f8926887e4e14f289a9f06f734d9b415
Source noteuspto-grants-1998_02