O-Methylhydroxylamine hydrochloride → 2-Bromophenylglyoxylic Acid Methyl Ester-O-methyloxime

Participants

Reaction Steps

5.2 g (62 mmol) of O-methylhydroxylamine hydrochloride is added to a solution of 10 g (41 mmol) of methyl 2-bromophenylglyoxylate in 30 ml of methanol, and the mixture is refluxed for 2 hours. The mixture is evaporated down, and the residue is taken up in ethyl acetate and washed with water. After drying and evaporating down, there remains 6.9 g (62%) of compound E.

Provenance & Evidence