反应详情

A mixture of ethyl 2-(6-fluoro-1-hydroxy-1-indanyl)acetate (2.0 g. 8.4 mmol), 1N lithium hydroxide (8.4 mL) and absolute ethanol (13.0 mL) was stirred for 18h at room temperature. The mixture was concentrated in vacuo, diluted with H2O and extracted with diethyl ether. The aqueous phase was concentrated in vacuo, diluted with toluene (100 mL) and concentrated in vacuo to give lithium 2-(6-fluoro-1-hydroxy-1-indanyl)acetate as a white solid (1.4 g, 77%); NMR (DMSO-d6): d 8.90 (s, 1H, OH), 6.88-7.18 (m, 3H, Ar), 2.55-2.83 (m, 2H, ArCH2), 2.13 (s, 2H, CH2CO), 1.88-2.07 (m, 2H, CH2).

1. concentrationThe mixture was concentrated in vacuo
2. additiondiluted with H2O
3. extractionextracted with diethyl ether
4. concentrationThe aqueous phase was concentrated in vacuo
5. additiondiluted with toluene (100 mL)
6. concentrationconcentrated in vacuo