反应详情

A suspension of sodium borohydride (0.60 g) and lithium bromide (1.66 g) in ethanol (17 ml) was stirred at room temperature for 25 minutes. Ethyl 2-amino-2-ethoxycarbonyl-4-(4-octylphenyl)butyrate (1.24 g) was dropwise added thereto over 3 minutes and the mixture was stirred at room temperature for 5 hours. Water (40 ml) was added to the reaction mixture and the mixture was stirred for 40 minutes. The crystals precipitated was collected by filtration and dried to give 0.68 g of the subject compound, melting point=125°-126° C. Treatment of the subject compound with hydrochloric acid-ethanol gives the corresponding hydrochloride.

1. waitover 3 minutes
2. stirringthe mixture was stirred at room temperature for 5 hours
3. stirringthe mixture was stirred for 40 minutes
4. customThe crystals precipitated
5. filtrationwas collected by filtration
6. customdried