反应详情

2-Chloro-5-nitroanisole (310 g, 1.7 mol) was taken up in a mixture of 48% HBr (1.5 L) and AcOH (1.2 L) and heated at reflux for 3 days. The dark solution was allowed to cool to room temperature, poured into ice water (10 L), and let stand for 3 h. The resultant dull yellow solid was filtered, washed with water, and dried in vacuo (230 g, 79%): mp 115–117° C.

1. temperatureheated
2. temperatureat reflux for 3 days
3. filtrationThe resultant dull yellow solid was filtered
4. washwashed with water
5. customdried in vacuo (230 g, 79%)