反应详情

To a stirred solution of 2.5 g of methyl 6-[([1,1'-Biphenyl]-2-carbonyl)amino]-pyridine-3-carboxylate in 50 ml of 1:1 tetrahydrofuran:methanol is added 10 ml of 5N sodium hydroxide and the mixture stirred at room temperature for 16 hours. The reaction mixture is concentrated in vacuo to a residue which is dissolved in water and neutralized with acetic acid. The separated colorless solid is filtered and air dried to give 2.0 g of the desired product: M+=318.

1. concentrationThe reaction mixture is concentrated in vacuo to a residue which
2. dissolutionis dissolved in water and neutralized with acetic acid
3. filtrationThe separated colorless solid is filtered
4. customair dried