Triethylamine → HCID 19699081, compound

HRID 863050Notes

Reaction equation

HRID 863050 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([NH2:24])[CH:21]=[CH:20][C:3]=1[C:4]([N:6]1[CH2:12][C:11]2[CH:13]=[CH:14][S:15][C:10]=2[CH2:9][C:8]2[N:16]=[CH:17][CH:18]=[CH:19][C:7]1=2)=[O:5].C(N(CC)CC)C.[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH3:42])=[C:37]([CH:41]=1)[C:38](Cl)=[O:39]>ClCCl>[S:15]1[C:10]2[CH2:9][C:8]3[N:16]=[CH:17][CH:18]=[CH:19][C:7]=3[N:6]([C:4]([C:3]3[CH:20]=[CH:21][C:22]([NH:24][C:38](=[O:39])[C:37]4[CH:41]=[C:33]([F:32])[CH:34]=[CH:35][C:36]=4[CH3:42])=[CH:23][C:2]=3[Cl:1])=[O:5])[CH2:12][C:11]=2[CH:13]=[CH:14]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27373835-Fluoro-2-methylbenzoyl chlorideHCID 19699089HCID 19699089, compound

Product 1

HCID 19699081HCID 19699081, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2 mmol of 5-(2-chloro-4-aminobenzoyl)-4,10-dihydro-5H-pyrido[3,2-b]thieno[2,3-e]azepine and 10 mmol of triethylamine in 25 ml of dichloromethane is added 2.1 mmol of 5-fluoro-2-methyl-benzoyl chloride. After stirring at room temperature overnight, the mixture is washed with H2O, 1M NaHCO3 and brine. The solution is dried (Na2SO4) and the solvent removed to give the product as a solid.

Workup

  1. washthe mixture is washed with H2O, 1M NaHCO3 and brine
  2. dry with materialThe solution is dried (Na2SO4)
  3. customthe solvent removed

Sources & evidence

ORD record
ord-0f1f3d6989924c51a298073020d32afd
Source dataset
uspto-grants-1998_02
Patent number
US05719278

Reaction notes

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