Triethylamine → HCID 19699061, compound

HRID 863052Notes

Reaction equation

HRID 863052 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([N:8]2[CH2:14][CH2:13][C:12]3[CH:15]=[N:16][O:17][C:11]=3[C:10]3[S:18][CH:19]=[CH:20][C:9]2=3)=[O:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.[F:30][C:31]1[CH:32]=[CH:33][C:34]([CH3:40])=[C:35]([CH:39]=1)[C:36](Cl)=[O:37]>ClCCl>[O:17]1[C:11]2[C:10]3[S:18][CH:19]=[CH:20][C:9]=3[N:8]([C:6]([C:5]3[CH:21]=[CH:22][C:2]([NH:1][C:36](=[O:37])[C:35]4[CH:39]=[C:31]([F:30])[CH:32]=[CH:33][C:34]=4[CH3:40])=[CH:3][CH:4]=3)=[O:7])[CH2:14][CH2:13][C:12]=2[CH:15]=[N:16]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27373835-Fluoro-2-methylbenzoyl chlorideHCID 19438750HCID 19438750, compound

Product 1

HCID 19699061HCID 19699061, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As described for Example 1, a solution of 2 mmol of 5,6-dihydro-6-(4-aminobenzoyl)-4H-isoxazolo [5,4-d]thieno[3,2-b]azepine and 5 mmol of triethylamine is reacted with 2.2 mmol of 5-fluoro-2-methylbenzoyl chloride in 10 ml of dichloromethane under argon for 16 hours to give the product as a solid.

Sources & evidence

ORD record
ord-62cca3925fc34faab757ff0e5b0cba9c
Source dataset
uspto-grants-1998_02
Patent number
US05719278

Reaction notes

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