4-Nitrophenyl formate → HCID 19697842, compound

HRID 863217Notes

Reaction equation

HRID 863217 reaction equation
[NH2:1][CH2:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[CH:10](OC1C=CC([N+]([O-])=O)=CC=1)=[O:11]>C(Cl)Cl>[CH:10]([NH:1][CH2:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5])=[O:11]

Participants

4

Reactant 2

HCID 746284-Nitrophenyl formateHCID 1780962-(Aminomethyl)aniline

Product 1

HCID 19697842HCID 19697842, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The amine component employed is prepared by reaction of 2.6 g of 2.6 g of 2-(aminomethyl)aniline, dissolved in 50 ml of methylene chloride, with 3.91 g of 4-nitrophenyl formate at room temperature for 4 h. Purification over 250 g of silica gel (mobile phase N) gives 2-(formylaminomethyl)aniline: Rf (N)=0.22.

Workup

  1. customPurification over 250 g of silica gel (mobile phase N)

Sources & evidence

ORD record
ord-06f3f0f8b54142149fdeeb9c52a2dca3
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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