Ammonia → HCID 13425071, compound

HRID 863240Notes

Reaction equation

HRID 863240 reaction equation
C[O:2][C:3]([CH:5]1[CH2:10][NH:9][C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[S:6]1)=O.[NH3:15]>CO>[C:3]([CH:5]1[CH2:10][NH:9][C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[S:6]1)(=[O:2])[NH2:15]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13425070Methyl 3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate

Product 1

HCID 13425071HCID 13425071, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

580 mg of 2(R,S)-methoxycarbonyl-3,4-dihydro-2H-1,4-benzothiazine are dissolved in 3 ml of a 6N ammonia solution in methanol and the solution is stirred at 50° C. for 16 h. Purification by chromatography over 50 g of silica gel gives 2(R,S)-carbamoyl-3,4-dihydro-2H-1,4-benzothiazine: Rf (Y)=0.19.

Workup

  1. customPurification by chromatography over 50 g of silica gel

Sources & evidence

ORD record
ord-e6c0c3fc455b48bcaf729e991ef68bf9
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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