Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate | HCID 13425070 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 13425071 | HCID 13425071 | — |
Reaction Steps
580 mg of 2(R,S)-methoxycarbonyl-3,4-dihydro-2H-1,4-benzothiazine are dissolved in 3 ml of a 6N ammonia solution in methanol and the solution is stirred at 50° C. for 16 h. Purification by chromatography over 50 g of silica gel gives 2(R,S)-carbamoyl-3,4-dihydro-2H-1,4-benzothiazine: Rf (Y)=0.19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05719141 |
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| Source dataset | uspto-grants-1998_02 |
|---|
| ORD ID | ord-e6c0c3fc455b48bcaf729e991ef68bf9 |
|---|
| Source note | uspto-grants-1998_02 |
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