3-Bromoquinoline → HCID 11332949, compound

HRID 863259Notes

Reaction equation

HRID 863259 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH2:12]([S-:14])[CH3:13].[Na+]>CN(C)C=O>[CH2:12]([S:14][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:13]

Participants

4

Reactant 2

HCID 214133-BromoquinolineHCID 4459711Sodium ethanethiolate

Product 1

HCID 11332949HCID 11332949, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Ethylthioquinoline is prepared starting from 2.1 g of 3-bromoquinoline and 4.2 g of sodium ethanethiolate in 30 ml of dimethylformamide analogously to Example 52d) and is purified by means of FC over 30 g of silica gel with a 1:2 mixture of diethyl ether and petroleum ether as the mobile phase. This gives the title compound: Rf (F)=0.31.

Workup

  1. customis purified by means of FC over 30 g of silica gel with a 1:2 mixture of diethyl ether and petroleum ether as the mobile phase

Sources & evidence

ORD record
ord-b0b65c8e1cee4588bbaeacb44cce87b8
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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