Methyl chloroformate → HCID 19697860, compound

HRID 863275Notes

Reaction equation

HRID 863275 reaction equation
Cl[C:2]([O:4][CH3:5])=[O:3].[NH2:6][C:7]1[CH:8]=[N:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[CH:12][CH:11]=2>C(Cl)Cl.N1C=CC=CC=1>[CH3:5][O:4][C:2]([NH:6][C:7]1[CH:8]=[N:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:3]

Participants

5

Reactant 2

HCID 6586Methyl chloroformateHCID 113753-Aminoquinoline

Product 1

HCID 19697860HCID 19697860, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

3.2 ml of methyl chloroformate am added dropwise to 5.0 g of 3-aminoquinoline in 30 ml of methylene chloride and 15 ml of pyridine at 0° C. in the course of 30 min. The mixture is subsequently stirred for a further 30 min and then worked up in the customary manner. The title compound is obtained as a crystalline solid: Rf (H)=0.41.

Sources & evidence

ORD record
ord-22f69287ca0f4d499aca345784f6d2de
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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