Methyl chloroformate → HCID 19697544, compound

HRID 863302Notes

Reaction equation

HRID 863302 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH2:4]1.Cl[C:14]([O:16][CH3:17])=[O:15]>>[CH3:17][O:16][C:14]([NH:1][CH2:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH2:4]1)=[O:15]

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 19697704HCID 19697704, compound

Product 1

HCID 19697544HCID 19697544, compound

Conditions

Temperature
0 °C

Procedure

The title compound is prepared from 3.1 g of 3(R,S)-aminomethyl-1,2,3,4-tetrahydroquinoline and 2.2 ml methyl chloroformate in an analogous manner to that described in Example 54) (stirring for 2 h at 0° C.) and is purified by chromatography over silica gel with a 1:2 mixture of hexane and ethyl acetate as the mobile phase: Rf (A)=0.25; FAB-MS: (M+H)+ =221.

Workup

  1. customis purified by chromatography over silica gel with a 1:2 mixture of hexane and ethyl acetate as the mobile phase

Sources & evidence

ORD record
ord-2991adee29554e4799a7210a94da1db8
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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