反应详情

温度

-20 °C

A mixture of (3-fluoropropyl)triphenylphosphonium bromide (14.7 g, 36.5 millimols) with THF (60 ml) was cooled down to -20° C., followed by adding t-BuOK (4.1 g, 36.5 millimols) to the mixture, stirring for one hour, dropwise adding to the mixture, a THF (50 ml) solution of trans-4-(2-(4-cyanophenyl)ethyl)cyclohexanecarbaldehyde (9.0 g, 30.2 millimols so as to keep the temperature at -20° C. or lower, stirring the mixture at the same temperature for 2 hours, and treating the product in the same manner as in Example 1 except that the quantity used for extraction was made 200 ml, to obtain raw 4-(2-(trans-4-(4-fluorobutenyl)cyclohexyl)ethyl)benzonitrile (8.1 g).

1. additiondropwise adding to the mixture
2. customat -20° C.
3. stirringlower, stirring the mixture at the same temperature for 2 hours
4. additiontreating the product in the same manner as in Example 1 except that the quantity
5. extractionused for extraction