Acetic Anhydride → 1-[4-Bromo-2-(methylsulphenylmethyl)phenyl]-3-cyclopropyl-2-ethoxymethylenepropane-1,3-dione

Participants

Reaction Steps

A mixture of 1-[4-bromo-2-(methylsulphenylmethyl)phenyl]-3-cyclopropylpropan-1,3-dione [4.4 g, containing approximately 1.0 g methyl 4-bromo-2-(methylsulphenylmethyl)benzoate], triethylorthoformate (3.5 ml) and acetic anhydride (2.9 ml) was heated at reflux for three hours. The mixture was then evaporated giving an impure sample of 1-[4-bromo-2-(methylsulphenylmethyl)phenyl]-3-cyclopropyl-2-ethoxymethylenepropane-1,3-dione as a red oil (4.8 g).

Provenance & Evidence