7-Hydroxymethyl-2-phenylbenzofuran → 2-Phenyl-benzo[b]furan-7-carboxaldehyde

HRID 863451Notes

Reaction equation

HRID 863451 reaction equation
[OH:1][CH2:2][C:3]1[C:8]2[O:9][C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:12]1([C:10]2[O:9][C:8]3[C:3]([CH:2]=[O:1])=[CH:4][CH:5]=[CH:6][C:7]=3[CH:11]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 145149497-Hydroxymethyl-2-phenylbenzofuran

Product 1

HCID 196964802-Phenyl-benzo[b]furan-7-carboxaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

12 g of manganese dioxide are added to 2 g of 7-hydroxymethyl-2-phenylbenzo [b]furan (prepared according to Example 1 from EP 306 226) in 100 ml of methylene chloride and the mixture is heated under reflux for 1 hour. It is cooled end filtered with suction over a filtering auxiliary, and the filtrate is concentrated.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 1 hour
  3. temperatureIt is cooled end
  4. filtrationfiltered with suction over a filtering auxiliary, and the filtrate
  5. concentrationis concentrated

Sources & evidence

ORD record
ord-6611e79c7f9b4fd9a9df49f5bc7356a7
Source dataset
uspto-grants-1998_02
Patent number
US05721248

Reaction notes

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