Sodium Bicarbonate → HCID 19430421, compound

HRID 863452Notes

Reaction equation

HRID 863452 reaction equation
CN(C)P(=O)(N(C)C)[S:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[CH3:12].C([O-])(O)=O.[Na+]>C(O)=O>[CH3:11][C:7]1[C:6]2[CH:12]=[C:12]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:5]=3)[S:4][C:5]=2[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 57132789HCID 57132789, compound

Product 1

HCID 19430421HCID 19430421, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

11 g (29.2 mmol) of the compound from Example XII are boiled under reflux in 50 ml of formic acid for 1 hour. The residue is neutralized with NaHCO3 solution and extracted with ethyl acetate and the extract is chromatographed over silica gel. The by-product from Example XIII can be removed particularly easily at this stage by distillation under a high vacuum, the title compound remaining as a solid.

Workup

  1. extractionextracted with ethyl acetate
  2. customthe extract is chromatographed over silica gel
  3. customThe by-product from Example XIII can be removed particularly easily at this stage by distillation under a high vacuum

Sources & evidence

ORD record
ord-84a8cd0850a74af6abc2d7856c42ca2a
Source dataset
uspto-grants-1998_02
Patent number
US05721248

Reaction notes

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