Bromine → HCID 19696170, compound

HRID 863486Notes

Reaction equation

HRID 863486 reaction equation
[N:1]([CH:4]1[CH2:13][C:12]2[C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5]1)=[N+:2]=[N-:3].[Br:18]Br>C(O)(=O)C>[N:1]([CH:4]1[CH2:13][C:12]2[C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:10][CH:9]=[C:8]([Br:18])[C:7]=2[CH2:6][CH2:5]1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 19696171HCID 19696171, compound

Product 1

HCID 19696170HCID 19696170, compoundYield 112.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N-(7-azido-5,6,7,8-tetrahydronaphthalen-1-yl)-acetamide (1 g, 4.3 mmol) in acetic acid (40 mL) was treated dropwise with bromine (1 g, 6.5 mmol) and stirred at room temperature for 3 h. The solvent was evaporated and the solid residue was washed with ether, collected by filtration and dried to give the product (1.5 g) in 89% yield.

Workup

  1. customThe solvent was evaporated
  2. washthe solid residue was washed with ether
  3. filtrationcollected by filtration
  4. customdried

Sources & evidence

ORD record
ord-be793dd56f2b47a18a249d2dbe8f96e4
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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