Sulfuric Acid → HCID 19696253, compound

HRID 863494Notes

Reaction equation

HRID 863494 reaction equation
C([NH:4][C:5]1[C:6]([N+:19]([O-:21])=[O:20])=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[CH2:10][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:8]2)(=O)C.S(=O)(=O)(O)O>O>[NH2:4][C:5]1[C:6]([N+:19]([O-:21])=[O:20])=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[CH2:10][CH:9]([NH:15][C:16](=[O:18])[CH3:17])[CH2:8]2

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 19696172HCID 19696172, compound

Product 1

HCID 19696253HCID 19696253, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

N-(5-Acetylamino-6-bromo-4-nitro-indan-2-yl)-acetamide (1 g, 2.8 mmol) was suspended in a 2:1 mixture of sulfuric acid and water (30 mL) and heated at 90° C. for 12 h. The mixture was poured onto ice and the resulting yellow solid was collected by filtration and dried in vacuo to give (0.7 g, 80% yield).

Workup

  1. additionThe mixture was poured onto ice
  2. filtrationthe resulting yellow solid was collected by filtration
  3. customdried in vacuo
  4. customto give (0.7 g, 80% yield)

Sources & evidence

ORD record
ord-7d9b6278e0c3488f98762565d183a9e4
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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