Nitric Acid → HCID 19696228, compound

HRID 863509Notes

Reaction equation

HRID 863509 reaction equation
Cl.[CH3:2][NH:3][CH:4]1[CH2:19][C:8]2[C:9]3[NH:10][C:11](=[O:18])[C:12](=[O:17])[NH:13][C:14]=3[CH:15]=[CH:16][C:7]=2[CH2:6][CH2:5]1.[N+:20]([O-])([OH:22])=[O:21]>FC(F)(F)C(O)=O>[CH3:2][NH:3][CH:4]1[CH2:19][C:8]2[C:9]3[NH:10][C:11](=[O:18])[C:12](=[O:17])[NH:13][C:14]=3[CH:15]=[C:16]([N+:20]([O-:22])=[O:21])[C:7]=2[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 19696181HCID 19696181, compound

Product 1

HCID 19696228HCID 19696228, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

9-Methylamino-1,2,3,4,7,8,9,10-octahydrobenzo[f]quinoxaline-2,3-dione hydrochloride (1 g, 3.5 mmol) was nitrated using fuming nitric acid (1 mL) and trifluoroacetic acid (30 mL) from 0° C. to room temperature for 1 h. The solvent was removed and their residue triturated in acetone:water and collected by filtration and dried to give the product (1.1 g). Calc'd for C13H14N4O4.HCl: C, 47.79; H, 4.63; N, 17.15; found: C, 43.36; H, 4.22; N, 18.85. MS M+1 (291).

Workup

  1. customfrom 0° C. to room temperature
  2. customfor 1 h
  3. customThe solvent was removed
  4. customtheir residue triturated in acetone
  5. filtrationwater and collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-6d410c8124c94db5bac88e246e85edf2
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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