Nitric Acid → HCID 19696154, compound

HRID 863528Notes

Reaction equation

HRID 863528 reaction equation
Cl.[CH3:2][N:3](C)[CH:4]1[CH2:18][C:7]2[C:8]3[NH:9][C:10](=[O:17])[C:11](=[O:16])[NH:12][C:13]=3[CH:14]=[CH:15][C:6]=2[CH2:5]1.[N+:20]([O-])([OH:22])=[O:21]>FC(F)(F)C(O)=O>[CH3:2][NH:3][CH:4]1[CH2:18][C:7]2[C:8]3[NH:9][C:10](=[O:17])[C:11](=[O:16])[NH:12][C:13]=3[CH:14]=[C:15]([N+:20]([O-:22])=[O:21])[C:6]=2[CH2:5]1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 19696177HCID 19696177, compound

Product 1

HCID 19696154HCID 19696154, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 8-dimethylamino-4,7,8,9-tetrahydro-1H-cyclopenta[f]quinoxaline-2,3-dione hydrochloride (0.39 g) in trifluoroacetic acid was cooled in an ice bath and then treated with fuming nitric acid (1 mL). After stirring for 1 h, the mixture was warmed to room temperature for 3 h. The solvent was evaporated and the residue suspended in methanol. The resulting yellow solid was collected by filtration and dried. Calc'd for C12H12 N4O4.CH4O3S: C, 41.93; H, 4.33; N, 15.05; found: C, 39.56; H, 4.11; N, 13,61. Ms M+1 (277).

Workup

  1. temperaturewas cooled in an ice bath
  2. customThe solvent was evaporated
  3. filtrationThe resulting yellow solid was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-d9122c40411547b18336db7a24b3f80f
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

Loading…