Acetic Anhydride → HCID 19696270, compound

HRID 863531Notes

Reaction equation

HRID 863531 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:20][C:6]2[C:7]3[NH:8][C:9](=[O:19])[C:10](=[O:18])[NH:11][C:12]=3[CH:13]=[C:14]([N+:15]([O-:17])=[O:16])[C:5]=2[CH2:4]1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C(N(CC)CC)C>O>[CH3:1][N:2]([CH:3]1[CH2:20][C:6]2[C:7]3[NH:8][C:9](=[O:19])[C:10](=[O:18])[NH:11][C:12]=3[CH:13]=[C:14]([N+:15]([O-:17])=[O:16])[C:5]=2[CH2:4]1)[C:21](=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 19696154HCID 19696154, compound

Product 1

HCID 19696270HCID 19696270, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 8-methylamino-6-nitro-4,7,8,9-tetrahydro-1H-cyclopenta[f]quinoxaline-2,3-dione (0.5 g. 1.6 mmol), acetic anhydride (0.5 g, 5 mmol), triethylamine (0.5 g, 5 mmol) in water (5 mL) was stirred for 15 min at room temperature. The solid was collected by filtration, washed with 2N HCl, then washed with diethyl ether and dried (0.5 g). Calc'd for C14 H14N4O5 : C, 52.83; H, 4.43; N, 17.60; found: C, 48.62; H, 4.26; N, 15.50.

Workup

  1. filtrationThe solid was collected by filtration
  2. washwashed with 2N HCl
  3. washwashed with diethyl ether
  4. customdried (0.5 g)

Sources & evidence

ORD record
ord-8745f30c4c9f42708064a29fe775054c
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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