HCID 22882815, compound → HCID 67590336, compound

HRID 863542Notes

Reaction equation

HRID 863542 reaction equation
CON(C)[C:4]([C@H:6]1[CH2:18][CH2:17][N:9]2[C:10]3[C:15]([CH:16]=[C:8]2[CH2:7]1)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[O:5].[CH:20]1([Mg]Cl)[CH2:24][CH2:23][CH2:22][CH2:21]1>C(OCC)C>[CH:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[CH:16]=[C:8]1[CH2:7][C@@H:6]([C:4]([CH:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:5])[CH2:18][CH2:17][N:9]12

Participants

4

Reactant 2

HCID 22882815HCID 22882815, compoundHCID 178478989HCID 178478989, compound

Product 1

HCID 67590336HCID 67590336, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In a manner analogous to that described in Example 11(iii), from 2.0 g (7.75 mmol) of 6,7,8,9-tetrahydro-N-methoxy-N-methylpyrido[1,2-a]indole-8(S)-carboxamide and 15 ml (30 mmol) of a 2M solution of cyclopentylmagnesium chloride in diethyl ether, there were obtained 1.1 g of cyclopentyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-8(S)-yl ketone as a pale yellow solid of melting point 69° C.

Sources & evidence

ORD record
ord-a8fb18e1e27d424cb868ae85e1f7bf78
Source dataset
uspto-grants-1998_02
Patent number
US05721230

Reaction notes

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