HCID 10058503, compound → HCID 10034961, compound

HRID 863569Notes

Reaction equation

HRID 863569 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]=1>CCOC(C)=O>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=1

Participants

3

Reactant 1

HCID 10058503HCID 10058503, compound

Product 1

HCID 10034961HCID 10034961, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-(1,3-Dioxolanyl)-5-aminopyridine was prepared from 2-(1,3-dioxolanyl)-5-nitropyridine by the procedure employed in Example V. Yield: 2.6 g (93%); mp 81°-82° C.; TLC Rf 0.18 (EtOAc); 1H NMR (90 MHz, CDCl3) δ 3.85 (br s, 2H, 5-NH2, D2O exchangeable), 4.05 (m, 4H, CH2CH2), 5.72 (s, 1H, 2-CH), 6.95 (dd, 1H, 4-H, J3,4 =8 Hz, J4,6 =2 Hz), 7.30 (d, 1H, 3-H, J3,4 =8 Hz) 8.08 (d, 1H, 6-H, J4,6 =2 Hz). Anal. (C8 H10N2O2) C, H, N.

Sources & evidence

ORD record
ord-eedab985928649f79c0c6e8230c535a1
Source dataset
uspto-grants-1998_02
Patent number
US05721259

Reaction notes

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