Benzyl Alcohol → HCID 54413221, compound

HRID 863622Notes

Reaction equation

HRID 863622 reaction equation
[C:1]([O:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[C:14]([F:17])([F:16])[F:15])[NH:7][C:6]=1[CH3:18])(=[O:3])[CH3:2].[Na].C(O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:1]([O:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[C:14]([F:17])([F:15])[F:16])[NH:7][C:6]=1[CH2:18][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 5360545SodiumHCID 54140225HCID 54140225, compound

Product 1

HCID 54413221HCID 54413221, compound

Procedure

A solution of 0.05 mole of methyl-(4-trifluoromethyl-3-indolyl) acetate and 0.01 mole of sodium in 60 ml. anhydrous benzyl alcohol is slowly fractioned over a period of 41/2 hours through a Vigreux column to remove methanol. The excess benzyl alcohol is removed by distillation at 60° and 2.5 mm. to give a residue of crude benzyl-(4-trifluoromethyl-3-indolyl) acetate.

Workup

  1. customto remove methanol
  2. customThe excess benzyl alcohol is removed by distillation at 60°

Sources & evidence

ORD record
ord-29cb80a2ef984b91a93adf5ed5dac9fc
Source dataset
uspto-grants-1998_02
Patent number
US05721347

Reaction notes

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