反应详情

To a solution of 500 ml. of 25% aqueous methylamine is added 93 g. (0.46 mole) of diethyl acetone-dicarboxylate. To the mixture is added 72 g. (0.782 mole) of chloroacetone over a 10 min. period. The temperature is kept below 60° C. by external cooling. After two hours, the mixture is poured into ice-hydrochloric acid. The solid is collected by filtration, washed with water and air dried. It is recrystallized from hexane to give ethyl 1,4-dimethyl-3-ethoxycarbonylpyrrole-2-acetate as a white solid, M.P. 71°-72° C.

1. additionTo the mixture is added 72 g
2. customis kept below 60° C. by external cooling
3. filtrationThe solid is collected by filtration
4. washwashed with water and air
5. customdried
6. customIt is recrystallized from hexane