反应详情

A solution of 3.67 g. (0.015 mole) of 5-(ρ-toluoyl)-1-methyl-pyrrole-2-acetonitrile, 24 ml. of 1N sodium hydroxide, and 50 ml. of 95% ethanol is stirred and refluxed for twenty-four hours. The resulting solution is poured into ice acidified with dilute hydrochloric acid. A white solid precipitates which is extracted into ether. The ether phase is washed with a saturated solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent is evaporated and a white solid, 5-ρ-toluoyl)-1-methylpyrrole-2-acetic acid, is obtained which is recrystallized twice from isopropanol, M.P., 155°-157° C.

1. temperaturerefluxed for twenty-four hours
2. additionThe resulting solution is poured into ice
3. customA white solid precipitates which
4. extractionis extracted into ether
5. washThe ether phase is washed with a saturated solution of sodium chloride
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent is evaporated