Sodium Hydroxide → HCID 54512127, compound

HRID 863639Notes

Reaction equation

HRID 863639 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21545860HCID 21545860, compound

Product 1

HCID 54512127HCID 54512127, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 8.0 g. (0.025 mole) of ethyl 5-(ρ-chlorobenzoyl)-1-methylpyrrole-2-propionate in 15 ml. ethanol and 30 ml. 1N sodium hydroxide is refluxed for one hour. The ethanol is then evaporated, and the remaining solution is poured into dilute hydrochloric acid. The remaining solution is poured into dilute hydrochloric acid. The resulting white precipitate is filtered off and purified by recrystallization from isopropyl alcohol, 5-(ρ-chlorobenzoyl)-1-methylpyrrole-2-propionic acid, M.P. 188°-191° C.

Workup

  1. additionA suspension of 8.0 g
  2. customThe ethanol is then evaporated
  3. additionthe remaining solution is poured into dilute hydrochloric acid
  4. additionThe remaining solution is poured into dilute hydrochloric acid
  5. filtrationThe resulting white precipitate is filtered off
  6. custompurified by recrystallization from isopropyl alcohol, 5-(ρ-chlorobenzoyl)-1-methylpyrrole-2-propionic acid, M.P. 188°-191° C.

Sources & evidence

ORD record
ord-34b98edeae014939aef468afbaf8ca8e
Source dataset
uspto-grants-1998_02
Patent number
US05721347

Reaction notes

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