Dimethylformamide → HCID 5327736, compound

HRID 863676Notes

Reaction equation

HRID 863676 reaction equation
[CH:1]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:2]=1[C:3]([C:14]1[C:15](=[O:30])O[C:17](=[O:29])[C:18]=1[C:19]1[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]([CH3:28])[CH:20]=1)=[C:4]1[CH2:13][CH2:12][CH2:11][CH2:10][N:5]12.C[N:32](C)C=O>N>[CH:1]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:2]=1[C:3]([C:14]1[C:15](=[O:30])[NH:32][C:17](=[O:29])[C:18]=1[C:19]1[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]([CH3:28])[CH:20]=1)=[C:4]1[CH2:13][CH2:12][CH2:11][CH2:10][N:5]12

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 10092139HCID 10092139, compound

Product 1

HCID 5327736HCID 5327736, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of 72 mg of 3-(6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-3-indolyl)furan-2,5-dione in 5 ml of dimethylformamide and 5 ml of 33% aqueous ammonia was heated to 140° C. for 4 hours. The resulting crystals were filtered off and dried to give 50 mg of 3-(6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 286°-289° C.

Workup

  1. filtrationThe resulting crystals were filtered off
  2. customdried

Sources & evidence

ORD record
ord-ebd40457cebc4f70b342705974203283
Source dataset
uspto-grants-1998_02
Patent number
US05721245

Reaction notes

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